Lonely people have a unique brain signature, perhaps due to so much imagined social contact

A new study of almost 40,000 adults has found that the brains of lonely people differ from those of people who are not lonely, in significant and detectable ways.

This loneliness “signature” consists of variations in the volume of different brain regions, and the way those brain regions communicate. And these variations may be related by the typical thinking patterns of lonely people, which include for example higher than average amounts of reminiscence and imaginary conversations.

The study compared the MRI scans of people who said they “often” feel lonely with the scans of people do not report feeling that way. The data comes from the UK Biobank, which is an open-source database with genetic and health information from about half a million people in the UK.

The 38,701 participants consisted of 47.5% men and 52.5% women. Their ages ranged from 40–69, with an average age of 55. About 13% of them answered “yes” to the question “Do you often feel lonely?” Of those who answered yes, about 39% were men, and 61% women.

The new paper appeared today (December 15) in Nature Communications.

Lonely people and the default network

The researchers behind the study, from McGill University in Montreal, found that the key differences involved the brain’s “ default network.” This network is responsible for a wide range of mental processes that take place when the brain is at rest. These processes are often referred to as the “inner voice”, or the “self.”

The default network plays a crucial role in memory, social cognition (i.e. thinking about other people), and mental time travel (“What will I do tomorrow?”). It involves the medial prefrontal cortex, and the posterior cingulate cortex, along with a number of other structures. It is also responsible for hallucinations and internal imagery.

The researchers discovered, unexpectedly, that volumes in several of these default network regions were larger in lonely people. They also found equally unexpected patterns of positive associations between some of these regions.

Feeling lonely: the typical thought patterns of lonely people

The association between the default network and loneliness may be because of the way lonely people tend to think. For example, they are more likely to call up past memories and ponder future scenarios. This may be a mechanism to help them escape from their loneliness.

The lonely might focus more on internal thoughts to compensate for their lack of actual social experiences. These thought patterns tend to include reminiscing and imagining desired social exchanges that have not actually taken place. And this increase in thoughts about the self might well influence the relationship between the regions of the default network.

“In the absence of desired social experiences,” the authors write, “lonely individuals may be biased towards internally directed cognitions,” as if “to fill the social void.”

In that sense, then, the physical effects of loneliness on the brain are not surprising. Paying “greater attention to one’s inner milieu, and a heightened focus on the self and self-reflective thoughts,” the authors write,”would naturally engage memory-based functions of the default network.”

Indeed, past research has found that lonely people are more likely to engage in imaginary social interactions, nostalgic reminiscences, and hypothetical conversations, and are also more likely to treat pets like people.

So lonely: why studying loneliness matters

Researchers are increasingly recognizing loneliness as a major health problem. A recent study, for example, found that loneliness has more than doubled among older people since the Covid-19 pandemic began.

Past research has also shown older people who experience loneliness have a higher risk of cognitive decline and dementia. Lonely people get sick more often, and take longer to get over infections. Loneliness also increases blood pressure and levels of stress hormones. Socially isolated people are more likely to be depressed, suffer from memory loss, and use alcohol and drugs. Likewise, evidence suggests that loneliness contributes to ageing in a number of ways, and leads to reduced longevity. In fact, the health risks of loneliness are equivalent to those related to obesity or smoking 15 cigarettes a day.

Understanding how loneliness works in the brain could one day help prevent neurological disease, and lead to better treatments.

“We speculate that the associations between the default network and loneliness revealed here,” the researcher write, “reflect increased demands on episodic mental simulation of inner social events in the absence of desired social experience in the external world.”

Study:The default network of the human brain is associated with perceived social isolation
Authors: Nathan Spreng et al.
Published in: Nature Communications
Publication date: December 15, 2020
DOI: http://dx.doi.org/10.1038/s41467-020-20039-w
Photo: by Anthony Tran via Unsplash

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Originally published at https://www.psychnewsdaily.com on December 15, 2020.



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PsychNewsDaily brings you the latest research from the worlds of psychology, cognitive science, mental health and more.